Pharmaceutical preparation for oral use
AssigneeAktiebolaget Hassle
InventorsKurt I. Lovgren, Ake G. Pilbrant, Mitsuru Yasumura, Satoshi Morigaki, Minoru Oda, Naohiro Ohishi
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Abstract
Pharmaceutical preparation containing omeprazole together with an alkaline reacting compound or an alkaline salt of omeprazole optionally together with an alkaline compound as the core material, one or more subcoating layers comprising inert reacting compounds which are soluble or rapidly disintegrating in water, or polymeric, water soluble filmforming compounds, optionally containing pH-buffering alkaline compounds and an enteric coating as well as a process for the preparation thereof and the use in the treatment of gastrointestinal diseases.
Claims14
An oral pharmaceutical preparation comprising
- (a) a core region comprising an effective amount of a material selected from the group consisting of omeprazole plus an alkaline reacting compound, an alkaline omeprazole salt plus an alkaline reacting compound and an alkaline omeprazole salt alone;
- (b) an inert subcoating which is soluble or rapidly disintegrating in water disposed on said core region, said subcoating comprising one or more layers of materials selected from among tablet excipients and polymeric film-forming compounds;
- and
- (c) an outer layer disposed on said subcoating comprising an enteric coating.
A process for the preparation of an oral pharmaceutical preparation containing omeprazole, comprising
- (a) preparing a core comprising an effective amount of a material selected from the group consisting of omeprazole plus an alkaline reacting compound, an alkaline omeprazole salt plus an alkaline reacting compound and an alkaline omeprazole salt alone;
- (b) coating the core with one or more layers of an inert subcoating material selected from among tablet excipients and polymeric film-forming compounds to form a subcoated core;
- and
- (c) coating the subcoated core with an enteric coating.
Dependencies are inferred from the claim text.