Cylindrical implants for the controlled release of growth hormones
AssigneeInternational Minerals & Chemical Corp.
InventorsAlvin M. Janski, Ren-Der Yang
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Abstract
This invention relates to a method for purifying and concentrating biologically active growth hormone to produce growth hormone in a form suitable for incorporation into a controlled release device (or system). A buffered solution of purified recombinant growth hormone is dialyzed against a buffered solution until the salt level is reduced to less than 5% and then lyophilized.
Claims7
A cylindrical implant for the controlled and continuous administration of growth hormone to a host comprising a compressed composition of an animal growth hormone produced by expression of a gene coding for the hormone in a transformant microorganism, said growth hormone being recovered from said microorganism and processed to produce a growth hormone containing less than 5% salt, and a biocompatible and growth hormone compatible polymer, said composition being surrounded along the length of the cylinder by a microporous polymer film and sealed at its ends by a non-porous polymer film.
Dependencies are inferred from the claim text.