Process for decreasing residual aldehyde levels in implantable bioprosthetic tissue
AssigneeBaxter Travenol Laboratories, Inc.
InventorsAws S. Nashef, Ronald Dieck
Life of this patent
Estimating the term…
Abstract
Residual aldehyde levels in bioprosthetic tissue are reduced by contacting the tissue with a rinsing solution such that aldehyde which has diffused out of the tissue into the rinsing solution comes into contact with, and reacts with, an amine, thus causing further diffusion of aldehyde out of said tissue. The amine may be dissolved in said rinsing solution or may be immobilized on a solid support to which the rinsing solution is periodically or continuously exposed.
Claims32
A method for decreasing residual tissue-fixing or tissue-sterilizing aldehyde levels in an implantable biological tissure previously contacted with said tissue-fixing or tissue-sterilizing aldehyde, comprising contacting said tissue with a rinsing solution to effect difusion of said aldehyde out of said tissue into said rinsing solution, said rinsing solution being water, saline or a buffered solution, and continuously or periodically contacting the rinsing solution with an aldehyde-reactive amine which is immobilized on a solid support, thus decreasing the concentration of said aldehyde in said rinsing solution and causing further diffusion of aldehyde out of said tissue.
Dependencies are inferred from the claim text.