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US 4,785,119 AGranted
3-aminopyrrolidine compound and process for preparation thereof
AssigneeTokyo Kasei Kogyo Co., Ltd.
InventorsKou Hojo, Anji Sakamoto, Masumi Tsutsumi, Tamotsu Yamada, Kazuhiko Nakazono, Kazuya Ishimori
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Abstract
Disclosed is a novel compound of 3-aminopyrrolidine having the formula (I): ##STR1## in which R.sup.1 is hydrogen, an alkyl, an aralkyl or an aryl.
Claims5
A process for preparing a compound of 3-aminopyrrolidine having the formula:
- ##STR6## in which R.sup.1 is hydrogen, which comprises reacting 1,2,4-trisubstituted butane having the formula:
- XCH.sub.2 CHYCH.sub.2 CH.sub.2 Z
- in which X, Y and Z each is a halogen or --OR, R being an alkylsulfonyl having 1 to 6 carbon atoms in the alkyl or an arylsulfonyl in which the aryl is phenyl or a phenyl substituted by methyl, methoxy, nitro or a halogen, with ammonia.
A process for preparing a compound of 3-aminopyrrolidine having the formula:
- ##STR7## in which R.sup.1 is an alkyl having 1 to 20 carbon atoms, phenyl, an aralkyl having 1 or 2 carbon atoms in the alkylene and 1 or 2 phenyls in the aryl or --CHR.sup.2 R.sup.3, R.sup.2 being phenyl or a phenyl substituted by methyl, methoxy, a halogen or nitro, R.sup.3 being hydrogen, an alkyl or phenyl, which comprises reacting 1,2,4-trisubstituted butane having the formula:
- XCH.sub.2 CHYCH.sub.2 CH.sub.2 Z
- in which X, Y and Z each is a halogen or --OR, R being an alkysulfonyl having 1 to 6 carbon atoms in the alkyl or an arylsulfonyl in which the aryl is phenyl or a phenyl substituted by methyl, methoxy, nitro and a halogen with a primary amine having the formula:
- R.sup.1 NH.sub.2
- in which R.sup.1 is as defined above.
2 more elements
A process for preparing 3-aminopyrrolidine comprising catalytically hydrogenating a compound of 3-aminopyrrolidine having the formula:
- ##STR8## in which R.sup.1 is an alkyl having 1 to 20 carbon atoms, phenyl, an aralkyl having 1 or 2 carbon atoms in the alkylene and 1 or 2 phenyls in the aryl or --CHR.sup.2 R.sup.3, R.sup.2 being phenyl or a phenyl substituted by methyl, methoxy, a halogen or nitro, R.sup.3 being hydrogen, an alkyl or phenyl or, salts of the compound, with a protonic acid.
Dependencies are inferred from the claim text.