Adsorbent and method of preparation
AssigneesResearch Development Corporation of Japan, Mitsubishi Kasei Corporation
InventorHideaki Kiniwa
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Abstract
A method of adsorbing a substance such as an optically active substance, comprising contacting a solution of the substance in a solvent with an adsorbent consisting of a cross-linked polymer comprising an optically active, synthetic poly(amino acid) represented by the general formula (I): ##STR1## wherein R stands for an organic group, R' stands for hydrogen or an alkyl group and n is an integer of at least 5, which may be protected at a terminal amino group and a carrier polymer supporting said synthetic poly(amino acid) thereon, said carrier polymer having affinity for said solvent. A method for producing the cross-linked polymer is also described. The adsorbent is especially useful for optical resolution of racemic mixtures.
Claims3
A cross-linked, polymeric material comprising an optically active, synthetic poly(amino acid) represented by the general formula (I):
- ##STR10## wherein R stands for an organic group, R' stands for hydrogen or an alkyl group and n is an integer of at least 5, and a terminal amino group protected as shown by the general formula (II):
- ##STR11## wherein R, R' each has the same meaning as above, R" stands for an organic group and m is an integer of at least 4, said polymeric material obtained by a process including the steps of:
- providing an amino group-containing, cross-linked polymer carrier in porous form,
- polymerizing an N-carboxy anhydride represented by the general formula:
- ##STR12## wherein R and R' each have the same meaning as above, in the presence of said carrier serving as an initiator to form a poly(amino acid) supported on said carrier and having terminal amino groups, and
- protecting the terminal amino groups with an organic group.
A method of producing a cross-linked polymeric material comprising an optically active, synthetic poly(amino acid) represented by the general formula (I):
- ##STR13## wherein R stands for an organic group, R' stands for hydrogen or an alkyl group and n is an integer of at least 5, including the steps of:
- polymerizing an N-carboxy anhydride represented by the general formula:
- ##STR14## wherein R and R' each have the same meaning as above, in the presence of an initiator to form a poly(amino acid), and
- reacting said poly(amino acid) with a cross-linked polymer carrier in porous form so that said poly(amino acid) is supported on said carrier.
Dependencies are inferred from the claim text.