3,4-dihydro-2H-1-benzopyran derivatives
AssigneeHoffmann-La Roche Inc.
InventorsNoal Cohen, Giuseppe F. Weber
Life of this patent
Estimating the term…
Abstract
The invention relates to compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or lower alkyl; R.sup.2 is hydrogen or halogen; R.sup.3, R.sup.4 and R.sup.5 are hydrogen, acyl or lower alkyl; R.sup.6 and R.sup.7, independently, are hydrogen or lower alkyl; X is alkylene.sub.3-7 ; and n is an integer of zero to four; provided that only one of R.sup.3, R.sup.4 or R.sup.5 can be acyl; enantiomers thereof, and, when R.sup.7 is hydrogen, salts thereof with pharmaceutically acceptable bases. The compounds of formulas I and II are useful as agents for the treatment of allergic conditions.
Claims13
A compound of the formula ##STR21## wherein R.sub.1 is hydrogen or lower alkyl;
- R.sup.2 is hydrogen or halogen, R.sup.3, R.sup.4 and R.sup.5, independently, are hydrogen, alkanoyl, benzoyl or lower alkyl;
- R.sup.6 and R.sup.7, independently, are hydrogen or lower alkyl;
- X is alkylene of 3 to 7 carbon atoms;
- and n is as an integer of one to four provided one of R.sup.3, R.sup.4 or R.sup.5 is alkanoyl or benzoyl and the other two, independently, are hydrogen or lower alkyl;
- or
- an enantiomer thereof, or, when R.sup.7 is hydrogen, a salt thereof, with a pharmaceutically acceptable base.
A pharmaceutical composition having SRS-A antagonistic activity, comprising an effective amount of a compound of the formula ##STR22## wherein R.sub.1 is hydrogen or lower alkyl;
- R.sup.2 is hydrogen or halogen;
- R.sup.3, R.sup.4 and R.sup.5, independently, are hydrogen, alkanoyl, benzoyl or lower alkyl;
- R.sup.6 and R.sup.7, independently, are hydrogen or lower alkyl;
- X is alkylene of 3 to 7 carbon atoms;
- and n is an integer of one to four;
- provided that one of R.sup.3, R.sup.4 or R.sup.5 is alkanoyl or benzoyl and the other two, independently, are hydrogen or lower alkyl;
- or
- an enantiomer thereof, or, when R.sup.7 is hydrogen, a salt thereof, with a pharmaceutically acceptable base, and an inert carrier material.
A method of treating allergic conditions requiring SRS-A antagonistic activity, which comprises administering an effective amount of a compound of the formula ##STR23## wherein R.sub.1 is hydrogen or lower alkyl;
- R.sup.2 is hydrogen or halogen;
- R.sup.3, R.sup.4 and R.sup.5, independently, are hydrogen, alkanoyl, benzoyl or lower alkyl;
- R.sup.6 and R.sup.7, independently, are hydrogen or lower alkyl;
- X is alkylene of 3 to 7 carbon atoms;
- and n is an integer of one to four;
- provided that one of R.sup.3, R.sup.4 or R.sup.5 is alkanoyl or benzoyl and the other two, independently, are hydrogen or lower alkyl;
- or
- an enantiomer thereof, or, when R.sup.7 is hydrogen, a salt thereof, with a pharmaceutically acceptable base.
Dependencies are inferred from the claim text.