Oxazole anthelmintic agents of marine origin
AssigneesSyntex Corporation, The Regents of the University of California
InventorsPhilip Crews, Thomas R. Matthews, Emilio Q. Cabana, Madeline Adamczeski
Life of this patent
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Abstract
New oxazole derivatives of formula 1 and their pharmacetically acceptable salts have anthelmintic activity: ##STR1## where R is H, OH, or acyloxy of 8 to 22 carbon atoms; R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are each independently H or acyl of 1 to 6 carbon atoms.
Claims20
A compund in substantially pure form of formula 1:
- ##STR7## where R is H, OH, or saturated acyloxy of 8 to 22 carbon atoms;
- R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are each independently H or acyl of 1 to 6 carbon atoms;
- and the pharmaceutically acceptable salts thereof.
A method for treating helminthiasis which method comprises administering to a subject in need thereof an effective amount of a compound in substantially pure form of formula 1:
- ##STR8## wherein R is H, OH, or saturated acyloxy of 8 to 22 carbon atoms;
- R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are each independently H or acyl of 1 to 6 carbon atoms;
- and the pharmaceuticlaly acceptable salts thereof or an effective amount of a phramaceutical composition wherein the active ingredient is a substantially pure form of the compound of formula 1 or its pharmaceutically acceptable salts.
A composition for treating helminthiasis, which comprises a pharmaceutically acceptable excipient and an effective amount of a compound in substantially pure form of formula 1:
- ##STR9## where R is H, OH, or saturated acyloxy of 8 to 22 carbon atoms;
- R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are each independently H or acyl of 1 to 6 carbon atoms;
- and the pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.