Drugs comprising 2,3- or 3,4-diphenyl derivatives of .gamma.-nitrile-esters or the cyclization products thereof
AssigneeLaboratoires Hoechst S.A.
InventorsJacques Dreux, Serge Petit
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Abstract
New drugs comprising 2,3- or 3,4-diphenyl derivatives of .gamma.-nitrile-esters or the products of cyclization of the 2,3-diphenyl derivatives according to the formulae A, B and C are claimed. Process for cyclization of 2,3-diphenyl derivatives of .gamma.-nitrile-esters, new 2,3-diphenyl derivatives of .gamma.-nitrile-esters corresponding to the formulae I to VIII are claimed; new 3,4-diphenyl derivatives of the said esters coresponding to the formulae IX and X, and new 3,4-diphenylpiperidone derivatives corresponding to the specific formulae IX to XXVII are described.
Claims5
A pharmaceutical composition, which comprises as an active ingredient an amount effective for use as a pharmaceutical in the therapy of a host of a cyclized 2,3 diphenyl derivative of .gamma.-nitrile-esters corresponding to the formula C ##STR2## in which, R is a hydrogen atom or a pharmaceutically compatible alkali metal or alkaline-earth metal or a C.sub.1 -C.sub.4 alkyl group, and X or Y which may be identical or different, are a hydrogen or halogen atom or a trifluoromethyl group, C.sub.1 -C.sub.4 alkyl, phenyl, phenyl-(C.sub.1 -C.sub.4 alkyl), C.sub.1 -C.sub.4 alkoxy, hydroxy, acyloxy, phenoxy, benzyloxy, C.sub.1 -C.sub.4 alkylsulfonyl or di(C.sub.1 -C.sub.4 alkyl)amino group, n being between 1 and 3 in the case where X and/or Y are other than hydrogen, and a pharmaceutically acceptacle carrier.
Dependencies are inferred from the claim text.