6-(6-alkylpyridone)-carbostyril compounds and their cardiotonic uses
AssigneeRorer Pharmaceutical Corporation
InventorsHenry F. Campbell, Donald E. Kuhla, Bruce F. Molino, William L. Studt
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Abstract
This invention relates to 6-pyridone-carbostyril compounds, uses of said compounds, including methods for increasing cardiac contractility, pharmaceutical compositions including the same and methods for the preparation thereof.
Claims6
A compound of the formula ##STR4## wherein:
- R, R.sub.1 and R.sub.2 are each independently H or lower alkyl;
- or a pharmaceutically acceptable salt thereof.
6-[3'-Cyano-6'-methyl-2'-oxo(1H)pyridin-5'-yl]-3,4-dihydrocarbostyril or a pharmaceutically acceptable salt thereof.
A method for increasing cardiac contractility in a human or other animal requiring such treatment which comprises administering thereto a composition comprising an effective inotropic amount of 6-[3'-cyano-6'-methyl-2'-oxo(1H)pyridin-5'-yl]-3,4-dihydrocarbostyril or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition for increasing cardiac contractility in a human or other animal requiring such treatment comprising an effective inotropic amount of 6-[3'-cyano-6'-methyl-2'-oxo(1H)pyridin-5'-yl]-3,4-dihydrocarbostyril or a pharmaceutically acceptable salt thereof in admixture with a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.