Method of treating patients suffering from chronic pain or chronic cough
AssigneeThe Rockefeller University
InventorsMary J. Kreek, Jack Fishman
Life of this patent
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Abstract
A method of treating patients in chronic pain or suffering from chronic cough over a prolonged period to provide systemic analgesia or central antitussive effect while simultaneously avoiding the onset of intestinal hypomotility. The method includes the oral administration to the patient of dosage units comprising in combination opioid analgesics or antitussives and selected opioid antagonists which are substantially devoid of systemic antagonist activity when administered orally.
Claims9
A method of treating a patient in chronic pain or suffering from chronic cough over a prolonged period to provide systemic analgesia or central antitussive effect while simultaneously avoiding the onset of intestinal hypomotility, comprising the oral administration to the patient 1-5 times daily of 1-2 dosage units comprising from about 1.5 to about 100 mg of an opioid analgesic or antitussive selected from the group consisting of methadone and propoxyphene and from about 1 to about 18 mg of an opioid antagonist or antagonist pro-drug substantially devoid of systemic antagonist activity when administered orally.
Dependencies are inferred from the claim text.