1-H-pyrido-[3,2-b][1,4]-thiazine
AssigneeBayer Aktiengesellschaft
InventorsAlexander Klausener, Gerd Fengler, Hans-Josef Buysch, Bernhard Pelster
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Abstract
1-H-pyrido-[3,2-b][1,4]-thiazines of the formula ##STR1## are prepared by the reaction of 2-halogenocarbonyl compounds an 2-amino-3-pyridinethiols. These compounds are useful as medicaments especially as inhibitors of lipoxygenase.
Claims7
A 1-H-pyrido[3,2-b][1,4]-thiazine of the formula ##STR66## in which R.sup.1 represents hydrogen, optionally substituted C.sub.1 to C.sub.8 alkyl or C.sub.2 to C.sub.8 -alkenyl, or the group ##STR67## in which R.sup.6 represents optionally substituted C.sub.1 to C.sub.8 alkyl, C.sub.1 to C.sub.8 alkoxy or C.sub.6 to C.sub.12 aryl,
- R.sup.2 represents hydrogen, nitrile, the group ##STR68## in which R.sup.7 represents optionally substituted C.sub.1 to C.sub.8 alkyl, or the group ##STR69## in which R.sup.8 and R.sup.9 each independently represent hydrogen, optionally substituted C.sub.1 to C.sub.8 alkyl or C.sub.6 to C.sub.12 aryl, and it being possible for the radicals R.sup.8 and R.sup.9 together with the nitrogen to which they are attached to form a 5- or 6-membered, optionally substituted heterocycle or additionally a pyrimidyl, imidazolyl, morpholinyl, thiomorpholinyl, piperazinyl or N-methyl piperazinyl, further R.sup.2 represents the group ##STR70## in which R.sup.10 represents optionally substituted C.sub.1 to C.sub.8 alkyl, it being possible for R.sup.1 and R.sup.10 to form an optionally substituted 5- to 8-membered carbocycle, or optionally substituted C.sub.6 to C.sub.12 aryl,
- R.sup.3 represents hydrogen, and
- R.sup.4 and R.sup.5 each independently represent hydrogen, halogen, optionally substituted C.sub.1 to C.sub.8 alkyl, C.sub.1 to C.sub.8 alkoxy, C.sub.6 to C.sub.12 aryloxy, C.sub.1 to C.sub.8 alkylthio, C.sub.6 to C.sub.12 arylthio or the group ##STR71## in which R.sup.11 and R.sup.12 each independently represent hydrogen, optionally substituted C.sub.1 to C.sub.8 alkyl, or C.sub.6 to C.sub.12 aryl, and it being possible for the radicals R.sup.11 and R.sup.12 together with the nitrogen to which they are attached to form a 5- or 6-membered, optionally substituted heterocycle and additionally a pyrimidyl, imidazolyl, morpholinyl, thiomorpholinyl piperazinyl or N-methyl piperizinyl, and salts thereof wherein the optional substituents mentioned for the radicals hereinabove are halogen, nitro, cyano, methoxycarbonyl, ethoxycarbonyl, and trifluoromethyl.
Dependencies are inferred from the claim text.