Pyrimidoindoles useful as hypoglycaemics
AssigneeJohn Wyeth & Brother Limited
InventorsAlan C. White, Ian A. Cliffe, Richard S. Todd
Life of this patent
Estimating the term…
Abstract
Compounds of formula ##STR1## wherein A represents a lower alkylene chain optionally containing one double or triple bond, RO represents (lower)alkoxy, aryl(lower)alkoxy, hydroxy or protected hydroxy, R.sup.1 and R.sup.2 which may be the same or different each represent hydrogen, hydroxyl, lower alkyl, lower alkoxy, halo(lower)alkyl, halogen, amino or mono- or di(lower)alkylamino and R.sup.3 and R.sup.4 each independently represent hydrogen or lower alkyl and their pharmaceutically acceptable acid addition salts are useful as hypoglycaemics or as intermediates for hypoglycaemics.
Claims17
A compound of the formula:
- ##STR9## in which A is alkylene of 1 to 6 carbon atoms;
- RO is hydroxy, alkoxy of 1 to 6 carbon atoms, phenylalkoxy of 7 to 12 carbon atoms or substituted phenylalkoxy of 7 to 12 carbon atoms, where the substituent on the phenyl ring is hydroxyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, haloalkyl of 1 to 6 carbon atoms, halo, amino, alkylamino of 1 to 6 carbon atoms or dialkylamino of 2 to 12 carbon atoms;
- R.sup.1 and R.sup.2 are, independently, hydrogen, hydroxyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, haloalkyl of 1 to 6 carbon atoms, halo, amino, alkylamino of 1 to 6 carbon atoms or dialkylamino of 2 to 12 carbon atoms;
- and
- R.sup.3 and R.sup.4 are, independently, hydrogen or alkyl of 1 to 6 carbon atoms;
- or a pharmaceutically acceptable salt thereof.
A method of treating diabetes which comprises administering to a mammal in need thereof a hypoglycemically effective amount of a compound of the formula:
- ##STR11## in which A is alkylene of 1 to 6 carbon atoms;
- RO is alkoxy, alkoxy of 1 to 6 carbon atoms, phenylalkoxy of 7 to 12 carbon atoms or substituted phenylalkoxy of 7 to 12 carbon atoms, where the substituent on the phenyl ring is hydroxyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, haloalkyl of 1 to 6 carbon atoms, halo, amino, alkylamino of 1 to 6 carbon atoms or dialkylamino of 2 to 12 carbon atoms;
- R.sup.1 and R.sup.2 are, independently, hydrogen, hydroxyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, haloalkyl of 1 to 6 carbon atoms, halo, amino, alkylamino of 1 to 6 carbon atoms or dialkylamino of 2 to 12 carbon atoms;
- and
- R.sup.3 and R.sup.4 are, independently, hydrogen or alkyl of 1 to 6 carbon atoms;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.