Controlled release tablet
AssigneeZyma SA
InventorKimon Ventouras
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Abstract
A controlled release tablet comprising (I) a core, containing as essential components (a) at least one water-soluble pharmaceutically active substance which is dispersed in a water-insoluble, non-digestible polymeric excipient, and (b) a water-insoluble polymeric substance, which is swellable under the influence of water, and (II) a coating essentially of an elastic, water-insoluble and semipermeable diffusion film of a polymer, is presented, which shows a release pattern for the active substance(s) in a programmed rate of approximately zero order.
Claims15
A controlled release tablet comprising
- (I) a core, containing as essential components
- (a1) at least one water-soluble pharmaceutically active substance;
- (a2) a water-insoluble, non-digestible polymeric excipient being a member of the group consisting of (i) polyvinylchloride and (ii) a homo- or copolymer of lower alkyl acrylates, lower alkyl methacrylates, or lower alkyl acrylate and lower alkyl methacrylate;
- and
- (b) a water-insoluble polymeric substance which is swellable under the influence of water being a member of the group consisting of hydroxypropylmethylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, alginic acid, sodium alginate, and cellulose, and
- (II) a coating consisting essentially of an elastic, water-insoluble and semipermeable diffusion film of a polymer.
A controlled release tablet comprising
- (I) a core, containing as essential components
- (a1) at least one water-soluble pharmaceutically active substance;
- (a2) a water-insoluble, non-digestible polymeric excipient being a member of the group consisting of (i) polyvinylchloride and (ii) a homo- or copolymer of lower alkyl acrylates, lower alkyl methacrylates, or lower alkyl acrylate and lower alkyl methacrylate;
- and
- (b) a water-insoluble polymeric substance which is swellable under the influence of water being a member of the group consisting of hydroxypropylmethylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, alginic acid, sodium alginate, and cellulose, and
- (II) a coating consisting essentially of an elastic, water-insoluble and semipermeable diffusion film of an ethyl acrylate/methyl methacrylate copolymer.
The controlled release tablet according to claim 17, in which the water-insoluble, non-digestible polymeric excipient is an ethylacrylate/methyl methacrylate copolymer.
The controlled tablet according to claim 17, in which the water-insoluble polymeric substance which is swellable under the influence of water is cellulose in microcrystalline form.
Dependencies are inferred from the claim text.