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US 4,784,734 AGranted
Azetidinone derivatives and process for the preparation of the same
AssigneeOtsuka Kagaku Yakuhin Kabushiki Kaisha
InventorsSigeru Torii, Kenji Uneyama, Hideo Tanaka, Junzo Nokami, Michio Sasaoka, Norio Saito, Takashi Shiroi
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Abstract
This invention provides azetidinone derivatives represented by the formula ##STR1## and processes for preparing the same. The azetidinone derivatives are used as the intermediates for producing cephalosporin compounds useful as antibiotic agents.
Claims4
A process for preparing an azetidinone derivative represented by the formula:
- ##STR103## wherein R.sup.1 is lower alkyl mono-substituted with aryl or with aryloxy, the aryl being optionally substituted with hydroxy, methoxy, chloro or nitro and the aryloxy being optionally substituted with hydroxy, methoxy or nitro;
- R.sup.2 is lower alkyl mono- or di-substituted with aryl or with aryloxy, the aryl being optionally substituted with methoxy, chloro or nitro, and the aryloxy being optionally substituted with nitro, or R.sup.2 is lower alkyl optionally mono- or tri-substituted with halogen;
- R.sup.5 is aryl optionally substituted with hydroxy, chloro, nitro, methyl or methoxy;
- and
- X' is a halogen, the process comprising subjecting to electrolysis an azetidinone derivative represented by the formula:
- ##STR104## wherein R.sup.1, R.sup.2 and R.sup.5 are as defined above in the presence of at least one member selected from the group consisting of hydrohalogenic acid and halide.
3 more elements
Dependencies are inferred from the claim text.