Influenza-A virus vaccine from fish cell cultures

Abstract

A method for preparing vaccines against influenza-A, and vaccines prepared thereby. Influenza-A virus is subjected to at least two passages in goldfish cell cultures, resulting in attenuated virus having reduced infectivity and somewhat altered antigenic characteristics relative to the starting virus, but which when used as a vaccine to innoculate mammalian species confers immunity. Immunization tests conducted in mice showed the vaccine to be effective.

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