Diagnostic methods for immune function
AssigneeImreg, Inc.
InventorA. Arthur Gottlieb
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Abstract
A diagnostic test is described for the assay of human and animal immune system response, in vitro. The test measures production in a peripheral blood lymphocyte population of a material that is an index of mitogen-induced immune response. Adaptations of the test are provided for the titration of amplifier dosage, and for a determination whether amplifier treatment is warranted for immunodeficient patients such as those with AIDS or ARC.
Claims25
A method of assaying human or animal immune system response that comprises the following steps:
- (1) Preparing a peripheral blood lymphocyte population from a blood sample taken from a human or animal subject;
- (2) Exposing a portion of said population to a mitogen and an amplifier;
- (3) Assaying the production in said population of a material that is an index of immune system response induced by said mitogen exposure.
A method of assaying the immune system response of a human test subject that comprises the following steps:
- (1) Preparing a peripheral blood lymphocyte population from a blood sample taken from said subject;
- (2) Exposing a portion of said population to a mitogen and an amplifier;
- (3) Assaying the production in said population of IL-2, by measuring the uptake of radioactively tagged thymidine, whereby an assay result is produced;
- and
- (4) repeating steps 2 and 3 at least one more time with a different concentration of amplifier in step 2.
Dependencies are inferred from the claim text.