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US 4,774,085 AGranted
Pharmaceutical administration systems containing a mixture of immunomodulators
Assignee501 Board of Regents, Univ. of Texas
InventorIsaiah J. Fidler
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Abstract
The present invention relates to pharmaceutical administration systems containing phosphatidylserine and phosphatidylcholine or phosphatidylethanolamine derivatives in the form of liposomes which encapsulate water soluble muramyldipeptide derivatives in combination with gamma-interferon. The liposomes are prepared by conventional dispersion methods. The pharmaceutical administration systems when applied in the form of liposomes are especially useful in the cancer chemotherapy for combating metastatic tumor cells.
Claims8
A pharmaceutical administration system consisting of
- (a) a water soluble muramylpeptide,
- (b) gamma-interferon,
- (c) a phospholipid of the formula ##STR7## wherein n is one, two or three, R.sub.1 and R.sub.2 independently of each other represent alkyl, alkenyl or acyl each having 10-20 carbon atoms, and Y.sup..sym. is the cation of a pharmaceutically acceptable base,
- (d) a phospholipid of the formula ##STR8## wherein n is two, three or four, R.sub.1 and R.sub.2 are defined as above and R.sub.3, R.sub.4 and R.sub.5 represent hydrogen or C.sub.1 -C.sub.4 -alkyl, and, optionally, a pharmaceutically acceptable carrier solution buffered to pH 7.0-7.8, and, optionally a pharmaceutically acceptable carrier in solid form.
1 more element
Dependencies are inferred from the claim text.