US 4,772,635 A · Bead-shaped crosslinked copolymers containing epoxide groups and basic amino groups, a process for their preparation and their use

Abstract

The invention relates to new bead-shaped crosslinked macroporous copolymers containing epoxide groups and basic amino groups, which are obtainable by reacting polymerizable glycidyl compounds, before or during free radical bead polymerization, which is carried out in the presence of agents which impart porosity and, if appropriate, with the addition of polyvinyl compounds which can be polymerized by free radical polymerization, with amines which are capable of reacting with at least two epoxide groups, a process for their preparation and their use, for example, for binding biologically active substances, for the preparation of strongly basic anion exchangers and hydrophilic chromatography resins for biomaterials.

Claims13

Dependent claims

A bead-shaped crosslinked macroporous copolymer which contains epoxide groups and basic amino groups and which is obtained by bead polymerizing a mixture comprising

(a) a polymerizable vinyl glycidyl compound,
(b) a porosity-imparting agent,
(c) a free radical-forming agent, and
(d) an amine capable of reacting with at least two epoxide groups and serving simultaneously as a crosslinking agent and as a basic modifier for the polymerizable glycidyl compounds, or comprising
(b) and (c) as defined, and
a pre-reaction product of (a) and (d) as defined,
the amine being present in an amount such that the content of epoxide groups in the crosslinked copolymer is 1 to 27% by weight, the copolymer exhibiting a greater capacity for fixing enzymes without deactivation compared with a comparable copolymer wherein the same amine (d) is post-reacted.

4 more elements

Dependencies are inferred from the claim text.

Bead-shaped crosslinked copolymers containing epoxide groups and basic amino groups, a process for their preparation and their use

Life of this patent

Bead-shaped crosslinked copolymers containing epoxide groups and basic amino groups, a process for their preparation and their use

Life of this patent

Abstract

Claims13