Method and ophthalmic composition for the prevention and reversal of cataracts
AssigneeThe Trustees of Columbia University in the City of New York
InventorsVincent P. Pigiet, Abraham Spector
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Abstract
The subject invention concerns a process for the prevention and reversal of cataracts. Specifically, the invention comprises the treatment of the eye lens with an effective cataract inhibiting amount of thioredoxin or thioredoxin-derived, or thioredoxin-like, dithiol peptide, alone, or in combination with a thioredoxin reductase regenerating system. The thioredoxin compound can be administered topically to a patient in need of such treatment on a daily basis over an extended period of time via known delivery techniques such as eye drops and ocular inserts.
Claims8
A process for the prevention and reversal of cataracts which comprises treating cells of mammalian eye lens with an effective cataract inhibiting amount of thioredoxin or thioredoxin-derived, or thioredoxin-like compound all from Escherichia coli, alone, or in combination with a reductase which reduces said thioredoxin, thioredoxin-derived or thioredoxin-like compound in association with an ophthalmologically acceptable carrier.
A composition of matter for the prevention and reversal of cataracts comprising thioredoxin or thioredoxin-derived, or thioredoxin-like, dithiol peptide from Escherichia coli, alone, or in combination with a reductase which reduces said thioredoxin, thioredoxin-derived or thioredoxin-like dithiol peptide in association with an ophthalmologically acceptable carrier wherein the concentration of the thioredoxin, thioredoxin-derived or thioredoxin-like compound is about 0.01 to about 10 mM.
Dependencies are inferred from the claim text.