Method and apparatus for calibrating plural pump fluid flow system

A method for deriving relative flow calibration data for an anticoagulant pump and a blood pump connected in a blood constituent processing system with a disposable plastic tubing which includes a common fluid path, said method comprising the steps of:

• installing a disposable plastic tubing into a blood constituent processing system and providing a common closed fluid path within the disposable tubing and extending between an anticoagulant pump and a blood pump;
• controlling the pumps to inject and/or withdraw fluid from said path at respective nominal rates;
• measuring a predetermined fluid parameter in said path during said controlling step;
• and
• deriving said relative flow characteristics in response to the controlling and/or measuring steps.

A method for calibrating relative pump flow rates of plural pumps connected with a common fluid-containing structure, said method comprising:

• controlling at least one of said pumps to pump liquid into said structure at a first nominal rate;
• simultaneously controlling at least one other of said pumps to pump liquid out of said structure at a second nominal rate;
• monitoring the fluid pressure or volume within said structure during said controlling step;
• and
• adjusting at least one of said nominal pump rates in response to said monitored fluid pressure or volume so as to obtain calibration data representing calibrated relative pump flow rates between plural pumps.

A method for calibrating a first pump flow with respect to a second pump flow in a blood constituent processing system, said method comprising the steps of:

• installing a disposable plastic tubing into said blood constituent processing system which includes a common fluid flow path between said first pump and said second pump;
• pumping fluid into said path with one of said pumps at a first predetermined nominal rate and pumping fluid out of said path with the other of said pumps at a second predetermined nominal rate, which rates are initially set to be at assumed equal values;
• detecting changes in fluid pressure or volume within said path caused by said pumping step;
• adjusting at least one of said first and second rates in response to said detecting step so as to maintain an approximately constant fluid pressure or volume within said path;
• and
• deriving a relative pump flow calibration factor based on the controlled nominal flow rates required by said adjusting step.

Apparatus for deriving relative flow calibration data for plural pumps connected with a common fluid path, said apparatus comprising:

• means for controlling said pumps to inject fluid into said path and/or to withdraw fluid from said path at respectively associated nominal rates;
• means for measuring changes in at least one fluid flow parameter occuring within said path in response to said injection of fluid into, and withdrawal of fluid from, said common fluid path;
• and
• means for deriving relative flow calibration data for the individual pumps in response to said measured changes.

Apparatus for deriving relative flow calibration data of first and second pumps connected in a blood constituent processing system with a disposable plastic tubing which includes a common fluid path between said pumps, said apparatus comprising:

• a disposable plastic tubing disposed in a blood constituent processing system and providing a common closed fluid path within the disposable tubing and extending between said first pump and said second pump;
• means for controlling the pumps to inject and/or withdraw fluid from said path at respective nominal rates;
• means for measuring a predetermined fluid parameter in said path;
• and
• means for deriving said relative flow calibration data in response to the effected pump control and/or the measured parameter.

Apparatus comprising:

• a system of plural pumps connected with a common fluid flow path;
• means for controlling at least two of the pumps to simultaneously inject and withdraw fluid from said path at relative rates which approximately maintain a constant fluid pressure or volume within said path;
• and
• means for measuring at least one relative pump flow calibration factor for said at least two pumps based on the controlled pumping rates required to approximately maintain said constant fluid pressure or volume.

Apparatus comprising:

• plural pumps connected with a common fluid-containing volume;
• means for controlling at least one of said pumps to pump liquid into said volume at a first nominal rate;
• means for simultaneously controlling at least one other of said pumps to pump liquid out of said volume at a second nominal rate;
• means for monitoring the fluid pressure or volume within said volume during said controlling step;
• and
• means for adjusting at least one of said nominal pump rates in response to said monitored fluid pressure or volume so as to obtain calibrated relative pump flow rates between plural pumps.

Apparatus for calibrating, during a preliminary set-up period, anticoagulant pump flow with respect to blood pump flow in a blood constituent processing system, said apparatus comprising:

• disposable plastic tubing located in a blood constituent process system which includes a closed fluid flow path between an anticoagulant pump connected to a source of anticoagulant solution and a blood pump connected to a source of saline solution;
• means for pumping fluid into said path with one of said pumps at a first predetermined nominal rate and pumping fluid out of said path with the other of said pumps at a second predetermined nominal rate, which rates are initially set to be at assumed equal values;
• means for detecting changes in fluid pressure within said path caused by said pumping;
• means for adjusting at least one of said first and second rates in response to said detected changes so as to maintain an approximately constant fluid pressure within said path;
• and
• means for deriving a relative pump flow calibration factor based on the controlled nominal flow rates required by said means for adjusting.

A method for automatically deriving relative flow calibration data for plural pumps connected with a common fluid path therebetween and a normally open fluid path which establishes fluid communication between the common fluid path and a fluid source, said method comprising:

• establishing a closed fluid path which includes said common fluid path by terminating, during a preliminary set-up period, fluid communication between said common fluid path and said fluid source;
• automaticallly controlling said pumps, during said preliminary set-up period, to inject fluid into said common fluid path and/or to withdraw fluid from said common fluid path at respectively associated nominal pumping rates;
• automatically measuring changes in at least one fluid flow parameter occuring within said closed common fluid path in response to said controlling of said pumps at said respectively associated nominal rates;
• and
• automatically deriving said relative flow calibration data for the individual pumps in response to said measured changes.

A method of operating a fluid system of the type having plural pumps connected with a common fluid path therebetween and a normally open fluid path which establishes fluid communication between the common fluid path and a fluid source, said method comprising:

• (a) deriving relative flow calibration data for said plural pumps by:
• (i) establishing a closed fluid path which includes said common fluid path by terminating, during a preliminary set-up period, fluid communication between said common fluid path and said fluid source;
• (ii) automatically controlling said pumps, during said preliminary set-up period, to inject fluid into said common fluid path and/or to wtihdraw fluid from said common fluid path at respectively associated nominal pumping rates;
• (iii) automatically measuring changes in at least one fluid flow parameter occuring within said closed common fluid path in response to said controlling of said pumps at said respectively associated nominal rate;
• and
• (iv) automatically deriving said relative flow calibration data for the individual pumps in response to said measured changes;
• and then
• (b) reestablishing, during a normal operating cycle after said preliminary set-up period, said normally open fluid path and controlling the operating rates of said plural pumps based upon said derived relative flow calibration data.

Apparatus for automatically deriving relative flow calibration data of plural pumps connected with a common fluid path therebetween and a normally open fluid path which establishes fluid communication between the common fluid path and a fluid source, said apparatus comprising:

• means for establishing a closed fluid path which includes said common fluid path by terminating, during a preliminary set-up period, fluid communication between said common fluid path and said fluid source;
• means for automatically controlling said pumps, during said preliminary set-up period, to inject fluid into said common fluid path and/or to withdraw fluid from said common fluid path ar respectively associated nominal pumping rates;
• means for automatically measuring changes in at least one fluid flow parameter occurring within said closed common fluid path in response to said controlling of said pumps at said respectively associated nominal rates;
• and
• means for automatically deriving said relative flow calibration data for the individual pumps in response to said measured changes.

A method for automatically deriving relative flow calibration data of plural pumps connected with a common fluid path therebetween, said method comprising the steps of:

• automatically controlling said pumps to inject fluid into said common fluid path and/or to withdraw from said common fluid path at respectively associated nominal pumping rates;
• automatically measuring changes in at least one fluid flow parameter occurring within said common fluid path in response to said controlling step of said pumps at said respectively associated nominal rates;
• comparing said measured changes in said at least one flow parameter to a predetermined standard value for said flow parameter;
• automatically continually modifying the pumping rate of at least one of said pumps from said nominal pumping rate thereof in response to said measured changes being at variance with said predetermined standard value until said measured changes are comparable to said predetermined standard value;
• and
• automatically deriving relative calibration data representative of said modified pumping rate of said at least one pump relative to said respective nominal rate thereof, whereby calibration data for the individual pumps using said measured changes is obtained.

A method for deriving a relative flow calibration data for plural pumps connected with a common fluid path, said method comprising the steps of:

• (a) operating said pumps at respective nominal pumping rate such that one pump injects fluid into said path and another pump withdraws fluid from said path;
• (b) measuring changes of at least one fluid flow parameter occurring within said common fluid path during said operation of said pumps at said respective nominal pumping rates and determining whether said measured changes are within a predetermined value which is required to maintain an approximately constant fluid pressure in said path while said one pump is injecting fluid into said path and said another pump is withdrawing fluid from said path;
• (c) modifying the pumping rate of said one and/or another pumps from said nominal pumping rate thereof until said changes of said at least one fluid flow parameter meausured according to step (b) is within said predetermined value;
• and
• (d) deriving a calibration value for said one and/or another pumps which is representative of said modified pumping rate, whereby calibration data for said pumps is obtained.

Apparatus for deriving relative flow calibration data for plural pumps connected with a common fluid path, said apparatus comprising:

• means for controlling said pumps to inject fluid into said path and/or to withdraw fluid from said path at respectively associated nominal rates;
• means for measuring changes in at least one fluid flow parameter occuring within said path in response to said injection of fluid into and withdrawal of fluid from said common fluid path;
• and
• means for deriving relative flow calibration data for the individual pumps, said means for deriving including;
• (i) means for comparing said measured changes in said at least one flow paratmeter to a predetermined standard value for said flow parameter;
• (ii) means for automatically continually modifying the pumping rate of at least one of said pumps from said nominal pumping rate thereof in response to said measured changes being at variance with said predetermined standard value until said measured changes are comparable to said predetermined standard value;
• and
• (iii) means for generating a calibration value representative of said modified pumping rate of said at least one pump relative to said respective nominal rate thereof, whereby calibration data for the individual pumps using said measured changes is obtained.