Method for detecting abnormal cell masses in animals
AssigneeThe Regents of the University of California
InventorDavid M. Long
Life of this patent
Estimating the term…
Abstract
An improved method of detecting abnormal cell mass in animals, particularly tumors, wherein a fluorocarbon emulsion and a lysophosphatide or proteinaceous material are administered to animals causing the fluorocarbon to be taken up by the cell mass in hithertofor unobtainable amounts, thus rendering it readily detectable by a variety of physical or chemical methods.
Claims17
A method for enhancing the detection of tumor cell mass in animals, comprising the steps of:
- forming an emulsion consisting of a radiopaque fluorocarbon at a concentration of about 10-50%, a lysophosphatide, said lysophosphatide being at a concentration of about 0.05-0.5%, and a phosphoglyceride at a concentration of about 1-5%;
- administering said emulsion in an amount sufficient to cause said emulsion to contact said tumor cell mass;
- and
- visualizing said tumor cell mass.
A method for enhancing the detection of tumor cell mass in animals, comprising the steps of:
- forming an emulsion of fluorocarbon at a concentration of about 10-50%, said fluorocarbon being radiopaque and selected from the group consisting of perfluorocarbon and perfluoroctylbromide, and a phosphoglyceride at a concentration of about 1-5%, and glucagon;
- administering said emulsion to animals in amounts sufficient to cause said emulsion to contact said tumor cell mass;
- and
- visualizing said emulsion present in said tumor cell mass.
A composition for distinguishing tumor cell mass from normal tissue, comprising:
- a fluorocarbon selected from the group consisting of perfluorocarbon and perfluoroctylbromide, said fluorocarbon being present in about 10-50%;
- a lysophosphatide at a concentration of about 0.05-0.5%;
- and
- an emulsifier being a phosphoglyceride at a concentration of about 1-5%.
A contrast composition useful for contrasting tumor cell mass from normal tissue, comprising:
- a fluorocarbon selected from the group consisting of perfluorocarbon an perfluoroctylbromide, said fluorocarbon being present in an amount of about 10-50%;
- glucagon present in an effective amount in said composition;
- and
- phosphoglyceride present at a concentration of about 1-5%.
A method for enhancing the detection of tumor cell mass in animals, comprising the steps of:
- forming an emulsion of fluorocarbon, said fluorocarbon being at a concentration of about 10-50%, said fluorocarbon being radiopaque and selected from the group consisting of perfluorocarbon and perfluoroctylbromide, and a phosphoglyceride at a concentration of about 1-5%, and insulin;
- administering said emulsion to animals in amounts sufficient to cause said emulsion to contract said tumor cell mass and;
- visualizing said emulsion present in said tumor cell mass.
A contrast composition useful for contrasting tumor cell mass from normal tissue patients, comprising:
- a fluorocarbon selected from the group consiting of perfluorocarbon and perfluoroctylbromide, said fluorocarbon being radiopaque and present at a concentration of about 10-50%;
- insulin at a concentration of about 10 micrograms-1 mg per kilogram of patient body weight;
- and
- a phosphoglyceride at a concentration of about 1-5%.
Dependencies are inferred from the claim text.