Human tissue plasminogen activator
AssigneeGenentech, Inc.
InventorsDavid V. Goeddel, William J. Kohr, Diane Pennica, Gordon A. Vehar
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Abstract
Human tissue phasminogen activator (t-PA) is produced in useful quantities using recombinant DNA techniques. The invention disclosed thus enables the production of t-PA free of contaminants with which it is ordinarily associated in its native cellular environment. Methods, expression vehicles and various host cells useful in its production are also disclosed.
Claims11
A DNA isolate consisting essentially of a DNA sequence encoding human tissue plasminogen activator.
A recombinant expression vector containing a DNA sequence encoding human tissue plasminogen activator, wherein the vector is capable of expressing human tissue plasminogen activator in a transformed microorganism or cell culture.
Dependencies are inferred from the claim text.