Antagonists of specific excitatory amino acid neurotransmitter receptors having increased potency

A potent, selective excitatory amino acid neurotransmitter receptor antagonist having the general formula:

• ##STR5## wherein R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of hydrogen, lower alkyl (C.sub.1 to C.sub.6), alkyl (C.sub.7 to C.sub.12), fatty acid chain (C.sub.13 to C.sub.24), aryl, aralkyl and hydroxyl;
• the stereoisomers being in their resolved or racemic form;
• n=1 and m=0, 1, 2 or 3;
• z=0, 1 or 2;
• and the pharmaceutically acceptable salts thereof.

A potent, selective excitatory amino acid neurotransmitter receptor antagonist having the general formula:

• ##STR6## wherein R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of hydrogen, lower alkyl (C.sub.1 to C.sub.6), alkyl (C.sub.7 to C.sub.12), fatty acid chain (C.sub.13 to C.sub.24), aryl, aralkyl, hydroxyl;
• the stereoisomers being in their resolved or racemic form;
• z=0, 1 or 2;
• the cycloalkyl ring being replaced with the cycloalkenyl ring;
• and the pharmaceutically acceptable salts thereof.