Insulin receptor
AssigneeGenentech, Inc.
InventorsJohn R. Bell, Janakiraman Ramachandran, Axel Ullrich
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Abstract
Insulin receptor is purified in accordance with this invention to a level sufficient to enable amino acid sequencing thereof. DNA encoding insulin receptor is provided, as well as methods for synthesizing insulin receptor or its mutant in heterologous host cells transformed with vectors containing such DNA. Knowledge of the amino acid sequence for insulin receptor enables the preparation of novel immunogenic conjugates and antibodies raised against such conjugates. Novel therapeutically useful forms of the insulin receptor and anti-receptor antibodies are described.
Claims13
Isolated DNA encoding an insulin receptor or a fragment thereof encoding a biologically active insulin receptor polypeptide.
Isolated DNA which encodes a biologically active insulin receptor and which is capable of hybridizing with the DNA of FIG. 1B.
An oligonucleotide probe that is capable of hybridizing with DNA that encodes an insulin receptor and which is labelled with a detectable moiety.
A vector comprising DNA encoding an insulin receptor of a fragment thereof encoding a biologically active insulin receptor polypeptide.
Dependencies are inferred from the claim text.