Pyrrothine derivatives and pharmaceutical use thereof
AssigneeBoehringer Mannheim GmbH
InventorsPeter Stahl, Hans Seidel, Herbert Von der Eltz, Otto-Henning Wilhelms, Androniki Roesch
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Abstract
There is described the use of pyrrothine derivatives of the general formula I ##STR1## wherein R.sub.1 and R.sub.3 signify hydrogen or methyl, R.sub.2 hydrogen, methyl or an acyl group with 1 to 5 carbon atoms and X and Y signify hydrogen, an equivalent of a physiolgically acceptable cation or together a single bond, for the inhibition of the allergen-induced degranulation of peripheral leukocytes.
Claims10
A method for the inhibition of allergen-induced degranulation of peripheral leukocytes comprising administering an effective amount of a pyrrothine derivative of the formula I ##STR8## wherein R.sub.1 is hydrogen or methyl, R.sub.2 is hydrogen, methyl or an acyl group with 1 to 5 carbon atoms, R.sub.3 is hydrogen or methyl and X and Y are hydrogen, an equivalent of a physiologically acceptable cation or together form a single bond.
A pyrrothine derivative compound of the formula I ##STR10## wherein R.sub.1, R.sub.2 and R.sub.3 are methyl and X and Y are hydrogen, an equivalent of a physiologically acceptable cation or together form a single bond.
A pharmaceutical composition for combating allergies containing an effective amount of a compound of formula I ##STR11## wherein R.sub.1 is hydrogen or methyl, R.sub.2 is hydrogen, methyl or an acyl group with 1 to 5 carbon atoms, R.sub.3 is hydrogen or methyl and X and Y are hydrogen, an equivalent of a physiologically acceptable cation or together form a single bond, in a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.