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US 4,759,923 AGranted
Process for lowering serum cholesterol using poly(diallylmethylamine) derivatives
AssigneeHercules Incorporated
InventorsGeorge A. Buntin, Bernard J. Scheve
Life of this patent
Estimating the term…
Abstract
It has been found that certain derivatives of poly(diallylmethylamine) are therapeutically effective serum cholesterol lowering agents.
Claims24
A method for lowering the blood serum cholesterol of an animal in need thereof comprising orally administering to the animal a therapeutically effective amount of a pharmaceutical compound selected from the group consisting of:
- (A) A quaternized poly(diallylmethylamine) cross-linked through about 0.03% to about 50% of its nitrogen radicals by heating at a temperature of at least about 200.degree. C. for a period of time sufficient to cross-link to the percentage desired;
- (B) Poly(diallylmethylamine) cross-linked through about 0.03% to about 50% of its nitrogen radicals by heating at a temperature below about 200.degree. C. in the presence of a multifunctional cross-linking agent and quaternized with a quaternizing agent before, during or after cross-linking;
- (C) A quaternized poly(diallylmethylamine) cross-linked through radiation by electron or gamma rays at a dose of about 2 to about 30 megarads;
- (D) Poly(diallylmethylamine) quaternized through about 1% to about 10% of its nitrogen radicals with hydrophobic saturated alkyl halide radicals having from about 6 to about 22 carbon atoms;
- and
- (E) Poly(diallylmethylamine) quaternized through about 1% to about 10% of its nitrogen radicals with a hydroxy substituted radical selected from the group consisting of derivatives of cholanic acid, derivatives of ergosterol, and derivatives of phenanthrene.
3 more elements
A pharmaceutical composition for lowering blood serum cholesterol comprising in unit dosage form from about 250 mg to about 7500 mg of a nontoxic pharmaceutical compound selected from the group consisting of:
- (A) A quaternized poly(diallylmethylamine) cross-linked through about 0.03% to about 50% of its nitrogen radicals by heating at a temperature of at least about 200.degree. C. for a period of time sufficient to cross-link to the percentage desired;
- (B) Poly(diallylmethylamine) cross-linked through about 0.03% to about 50% of its nitrogen radicals by heating at a temperature below about 200.degree. C. in the presence of a multifunctional cross-linking agent and quaternized with a quaternizing agent before, during or after cross-linking;
- (C) A quaternized poly(diallylmethylamine) cross-linked through radiation by electron or gamma rays at a dose of about 2 to about 30 megarads;
- (D) Poly(diallylmethylamine) quaternized through about 1% to about 10% of its nitrogen radicals with hydrophobic saturated alkyl halide radicals having from about 6 to about 22 carbon atoms;
- and
- (E) Poly(diallylmethylamine) quaternized through about 1% to about 10% of its nitrogen radicals with a hydroxy substituted radical selected from the group consisting of derivatives of cholanic acid, derivatives of ergosterol, and derivatives of phenanthrene.
3 more elements
Dependencies are inferred from the claim text.