Diaminocyclohexane platinum complexes
AssigneeResearch Corporation Technologies, Inc.
InventorsDavid B. Brown, deceased, Abdul R. Khokhar, Miles P. Hacker, John J. McCormack
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AssigneeResearch Corporation Technologies, Inc.
InventorsDavid B. Brown, deceased, Abdul R. Khokhar, Miles P. Hacker, John J. McCormack
Estimating the term…
Diaminocyclohexane platinum complexes having the structural formula ##STR1## wherein: X is a monovalent anion selected from the group consisting of isoascorbate, monosaccharate, saccharate-4-lactone, shikimate, isethionate, 2-aminoethylsulfate, azetidinecarboxylate, proline, hydroxyproline, pipecolinate, cyclopropanecarboxylate, cxyclobutanecarboxylate, cyclopentanecarboxylate, cyclopentenecarboxylate, cyclohexanecarboxylate, cyclohexenecarboxylate, bicine, glycine, 2-aminoethanesulfonate, 2-chloroethanesulfonate and Y is a divalent anion selected from the group consisting of iminodiacetate, isocitratelactone, furanedicarboxylate, cyclopropane-1,1-dicarboxylate, isocitratomonoethylester, N-methyliminodiacetate, N-(2-hydroxyethyl)-iminodiacetate, N-benzyliminodiacetate, N-phenyliminodiacetate, N-(2-acetamido)-iminodiacetate, cyclohexane-1,1-diacetate, trans-1,2-cyclopropanedicarboxylate, trans-1,2-cyclobutanedicarboxylate, trans-1,2-cyclopentanedicarboxylate and trans-1,2-cyclohexanedicarboxylate and their use in the treatment of tumors.
A method of treating an animal afflicted with tumor cells sensitive to a water-soluble square-planar DACH cis-platinum (II) four-coordinate complex having the formula:
Dependencies are inferred from the claim text.