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US 4,758,583 AGranted
Method and agents for inhibiting protein aging
AssigneeThe Rockefeller University
InventorsAnthony Cerami, Peter C. Ulrich, Michael Brownlee
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AssigneeThe Rockefeller University
InventorsAnthony Cerami, Peter C. Ulrich, Michael Brownlee
Estimating the term…
The present invention relates to compositions and methods for inhibiting protein aging. Accordingly, a composition is disclosed which comprises an agent or compound capable of inhibiting the formation of advanced glycosylation end products of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. Suitable agents may contain an active nitrogen-containing group, such as a hydrazine group, and may further be at least partially derived from amino acids. Particular agents comprise aminoguanidine, .alpha.-hydrazinohistidine and lysine. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
A method for inhibiting the advanced glycosylation of a target protein comprising contacting the target protein with an amount effective to inhibit the formation of advanced glycosylation end products of a composition comprising an agent capable of reacting with the carbonyl moiety of the early glycosylation product formed by the initial glycosylation of the target protein.
Dependencies are inferred from the claim text.