US 4,756,884 AGranted

Capillary flow device

AssigneeBiotrack, Inc.

InventorsRobert S. Hillman, Michael E. Cobb, Jim Allen, Ian Gibbons, Vladimir Ostoich, Laura J. Winfrey

Life of this patent

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Abstract

Methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastic devices is also described along with various control devices for use with the device.

Claims12

Dependent claims

An analytical device for detecting the presence of an analyte in a physiological fluid sample, comprising:

a housing containing an inlet port, a chamber unit, an exit port, a first capillary unit for independently pumping a liquid from said inlet port to said chamber unit, and a second capillary unit positioned between and operatively connected to said chamber unit and said exit port for independently pumping a liquid from said chamber unit to said exit port;
wherein said inlet port, first capillary unit, chamber unit, second capillary unit, and exit port are present in a continuous capillary pathway;
said housing further containing a reagent in said capillary pathway comprising a member selected from the group consisting of compounds affecting blood clotting and antibodies capable of causing a change in flow rate of said fluid sample in said pathway.

Dependencies are inferred from the claim text.

Facts

Application: 06/880,793Filed 1 Jul 1986 · continuation in part
Priority: 5 Aug 1985
Granted: 12 Jul 1988
Term ends: Not estimatedThe source records don’t support an estimate.

Classification43 codes

G01N 33/4905
Blood: determining clotting time of blood
B01F 25/4316
Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor: the baffles being flat pieces of…
B01F 25/433
Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction: mixing tubes wherein the shape of the tube influences…
B01F 25/4338
Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly…