Propenylamines, pharmaceutical compositions containing them and their use as pharmaceuticals
AssigneeSandoz Ltd.
InventorAnton Stuetz
Life of this patent
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Abstract
A compound of the formula: ##STR1## wherein the double bond is in the trans configuration and R.sub.1 is a radical of formula IIa, ##STR2## R.sub.2, R.sub.3, R.sub.5, R.sub.7 and R.sub.8 are each hydrogen, R.sub.4 is methyl, and R.sub.6 is a radical of formula IIIa --C.tbd.C--R.sub.11 IIIa where R.sub.11 is n-butyl, tertiary butyl or phenyl or a chemotherapeutically acceptable acid addition salt thereof; processes for their production, their use as pharmaceuticals and pharmaceutical compositions containing them.
Claims7
A compound of the formula:
- ##STR78## wherein the double bond is in the trans configuration and R.sub.1 is a radical of formula IIa, ##STR79## R.sub.2, R.sub.3, R.sub.5, R.sub.7 and R.sub.8 are each hydrogen, R.sub.4 is methyl, and
- R.sub.6 is a radical of formula IIIa
- --C.tbd.C--R.sub.11 IIIa
- where R.sub.11 is n-butyl, tertiary butyl or phenyl or a chemotherapeutically acceptable acid addition salt thereof.
N-Methyl-N-(1-naphthylmethyl)-non-2(trans)en-4-ynyl-1-amine or a chemotherapeutically acceptable acid addition salt thereof.
N-Methyl-N-(1-naphthylmethyl)-6,6-dimethylhept-2(trans)-e n-4-ynyl-1-amine or a chemotherapeutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.