Peptides for the diagnosis of HTLV-III antibodies, their preparation and use
AssigneeCambridge Bioscience Corporation
InventorsGerald A. Beltz, Richard M. Thorn, Dante J. Marciani, Chung-Ho Hung, William A. Haseltine
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Abstract
Certain peptide fragments of the human T-cell leukemia (lymphotropic) virus (HTLV-III) are particularly immunoreactive to HTLV-III antibodies, and can therefore be applied to immunodiagnostic tests for the detection of antibodies to HTLV-III.
Claims17
A peptide fragment which is immunoreactive to antibodies against the HTLV-III virus and is encoded by a nucleotide sequence of the HTLV-III provirus as shown in FIG. 19 from about 7199 to about 7349, about 7419 to about 7850, and about 7917 to about 8052.
A peptide fragment which is immunoreactive to antibodies against the HTLV-III provirus and encoded by a nucleotide sequence as shown in FIGS. 18 and 19 from about 6827 to about 7349, about 7419 to about 7850, and about 7917 to about 8052.
A peptide fragment which is immunoreactive to antibodies against the HTLV-III virus and is encoded by a nucleotide sequence as shown in FIG. 21 of the HTLV-III provirus from about 6827 to about 6936, about 6952 to about 7349, and about 7419 to about 7802.
A kit for detecting the HTLV-III virus or portions thereof in a sample comprising a carrier being compartmentalized to receive one or more container means in close confinement therein, a first container means containing a first antibody according to claim 4 immobilized on a solid phase immunoabsorbent and second container means comprising a detectably labeled second antibody according to claim 33 which is cross-reactive with a different domain of the HTLV-III virus from said first antibody or having a detectably labeled anti-antibody to said first antibody.
Dependencies are inferred from the claim text.