Back to results
US 4,752,614 AGranted
Pharmaceutical compositions of tellerium and selenium compounds for the induction of in vivo and in vitro production of cytokines
AssigneeBar-Ilan University
InventorsMichael Albeck, Benjamin Sredni
Life of this patent
Estimating the term…
Abstract
Certain tellurium compounds have been found to have the ability to stimulate the in vivo and in vitro production of cytokines and their receptors. These compounds may be utilized in the treatment of certain tumors, autoimmune diseases, immune diseases and infectious diseases.
Claims6
A pharmaceutical composition which comprises a pharmaceutically acceptable carrier and a compound of the formula:
- ##STR13## wherein Q is Te or Se;
- t is 1 or 0;
- u is 1 or 0;
- v is 1 or 0;
- R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are the same or different and are independently selected from the group consisting of hydrogen, hydroxyalkyl of 1 to 5 carbons, hydroxy, alkyl of from 1 to 5 carbon atoms, halogen, haloalkyl of 1 to 5 carbon atoms, carboxy, alkylcarbonylalkyl of 2 to 10 carbons, alkanoyloxy of 1 to 5 carbon atoms, carboxyalkyl of 1 to 5 carbon atoms, acyl, amido, cyano, amidoalkyl of 1 to 5 carbons, N-monoalkylamidoalkyl of 2 to 10 carbons, N,N-dialkylamidoalkyl of 4 to 10 carbons, cyanoalkyl of 1 to 5 carbons, alkoxy of 1 to 5 carbon atoms, alkoxyalkyl of 2 to 10 carbon atoms and --COR.sub.10 wherein R.sub.10 is alkyl of from 1 to 5 carbons;
- and X is halogen;
- R.sub.11, R.sub.12, R.sub.13 and R.sub.14 are independently selected from the group consisting of hydrogen, hydroxyalkyl of 1-5 carbon atoms, hydroxy and alkyl of 1-5 carbon atoms.
4 more elements
Dependencies are inferred from the claim text.