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US 4,752,601 AGranted
Method of blocking immune complex binding to immunoglobulin FC receptors
AssigneeImmunetech Pharmaceuticals
InventorGary S. Hahn
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Abstract
A method of modulating immune complex mediated immune responses in mammals is described, comprising administering a peptide comprising the amino acid sequence -Thr-Ile-Ser-Lys-Ala-Lys-Gly-Gln-Pro-Arg- Specific uses in reducing immune complex mediated inflammation or tissue destruction and in modulating the proliferation or function of mononuclear cells are disclosed.
Claims3
A method of modulating an immune complex mediated immune response in a mammal, comprising administering to a mammal an effective amount to block immune complex binding to immunoglobulin Fc receptors of a peptide having the amino acid sequence
- Thr-Ile-Ser-Lys-Ala-Lys-Gly-Gln-Pro-Arg-B,
- wherein B is a substituent selected from the group consisting of
- -OH,
- -Glu,
- -Glu-Pro,
- -Glu-Pro-Gln,
- -Glu-Pro-Gln-Val and
- -Glu-Pro-Gln-Val-Tyr;
- and pharmaceutically acceptable salts of said peptide.
6 more elements
Dependencies are inferred from the claim text.