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US 4,751,286 AGranted
Protein label and drug delivery system
AssigneeThe Johns Hopkins University
InventorsBeverly Packard, Michael Edidin, Akira Komoriya
Life of this patent
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Abstract
A bridging molecule carrying a drug, or a label such as a fluorophore, which adds across disulfide bonds of molecules, particularly proteins, and methods of manufacturing and using the bridging molecules, are disclosed. The bridging molecule is reactive with sulfhydryl groups formed by the reduction of disulfide bonds of the protein. The functional groups of the bridging molecules are typically --SH groups.
Claims14
A compound capable of a bridging reaction with sulfhydryl groups formed by the reduction of disulfide bonds of a protein, said compound having the formula:
- ##STR8## wherein A comprises a drug, dye or label portion which is unreactive with sulfhydryl groups;
- and X and Y comprise functional groups reactive with separate sulfhydryl groups formed by reduction of disulfide bonds of a protein molecule.
Dependencies are inferred from the claim text.