Method and apparatus for measuring blood glucose concentration
AssigneeXienta, Inc.
InventorsRichard Reinhart, Fred Letterio, Peter Pugliese, Carl Ritter, Glenn Lubrano, Jerry Guilbault, Christopher Feistel
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Abstract
A non-invasive method for measuring blood glucose concentration using glucose present at the mucosal surface of a living being is provided. The method includes the steps of positioning a glucose oxidase membrane on the mucosal surface, providing oxygen for peroxidative oxidation of the glucose present thereat, electrically measuring the amount of hydrogen peroxide product and calibrating that amount to determine blood glucose concentration. Also provided are electrode devices suitable for carrying out the method.
Claims41
An apparatus suitable for use in measuring blood glucose concentration in a living being using glucose which is present at the buccal mucosal surface of said being, said apparatus comprising:
- membrane means for containing glucose oxidase enzyme;
- means for positioning the said membrane means against said buccal mucosal surface;
- means for providing oxygen for said membrane means, said provided oxygen used for peroxidative oxidation of said glucose when said membrane means is positioned against said mucosal surface, said oxidation yielding hydrogen peroxide as a product;
- and
- means for measuring in said membrane means changes in the concentration of at least one compound selected from the group including said provided oxygen and said hydrogen peroxide product.
A method of measuring blood glucose concentration in a living being using glucose which is present at a mucosal surface located in an orifice of said being, said method comprising:
- positioning a membrane member against said mucosal surface, said membrane member including glucose oxidase enzyme;
- providing oxygen to said membrane member to enable peroxidative oxidation of said glucose, said oxidation producing hydrogen peroxide as a product;
- measuring the change in concentration of at least one compound selected from the group including said provided oxygen and said hydrogen peroxide product;
- and
- calibrating said measurement in order to determine blood glucose concentration.
An apparatus suitable for use in measuring blood glucose concentration in a living being using glucose which is present at a mucosal surface of said being, said apparatus comprising:
- membrane means for containing glucose oxidase enzyme;
- means for positioning said membrane means against said mucosal surface;
- means for providing oxygen for said membrane means, said provided oxygen used for peroxidative oxidation of said glucose when said membrane means is positioned against said mucosal surface, said oxidation yielding hydrogen peroxide as a product;
- and
- means for measuring in said membrane means changes in the concentration of at least one compound selected from the group including said provided oxygen and said hydrogen peroxide product.
Dependencies are inferred from the claim text.