Antibiotic bonded prosthesis and process for producing same
AssigneesUniversity of Medicine and Dentistry of New Jersey, Rutgers University
InventorsRalph S. Greco, Richard A. Harvey, Stanley Z. Trooskin, George Strauss
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Abstract
There is disclosed an improved prosthesis coated, respectively, with an ionic surfactant, an antibiotic and/or antithrombiotic agent and treated with an immobilizing ionic exchange compound, to remove un-antibiotic bound ionic surfactant. The drug may be encapsulated within phospholipid vesicles which are bound to the prosthesis.
Claims20
A prosthesis for use in in vivo surgery having a coating, respectively, of an ionically charged surfactant and an antibiotic compound encapsulated within phospholipid vesicles, wherein said vesicles have a surface charge opposite to that of said surfactant.
A method for preparing a prosthesis for use in in vivo surgery, which comprises:
- (a) contacting said prosthesis with an ionically charged surfactant to coat said prosthesis with said ionically charged surfactant;
- (b) contacting said prosthesis of step (a) with a phospholipid vesicle suspension;
- and
- (c) removing non-adhering vesicles from the prosthesis of step (b).
Dependencies are inferred from the claim text.