Targeting conjugates of albumin and therapeutic agents
AssigneeThe Governors of the University of Alberta
InventorMark J. Poznansky
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Abstract
The invention provides a conjugate comprising an enzyme having its antigenic sites or antigenicity masked by albumin and having a targeting agent attached, and a method for its preparation. The albumin is included in an amount sufficient to mask antigenicity of the enzyme. The targeting agent used has binding specificity for receptor sites on cells towards which it is desirable to direct the enzyme. Insulin, immunoglobulin G, antibody against human pancreatic tumor cell, and antibody against hyaluronic acid are exemplified as targeting agents.
Claims11
A water soluble, sterile and non-immunogenic composition of matter, comprising an enzyme selected from the group consisting of .alpha.-1,4-glucosidase, L-asparaginase, and superoxide dismutase, said enzyme chemically linked to homologous albumin, and a targeting agent chemically linked to the albumin, the amount of albumin being sufficient to mask antigenicity of the enzyme, and the targeting agent having binding specificity for receptor sites on cells to which it is desirable to direct the enzyme.
Dependencies are inferred from the claim text.