Serial dilution of liquid samples
AssigneeSwelab Instrument AB
InventorL. Erik Ohlin
Life of this patent
Estimating the term…
Abstract
An apparatus and method for serial dilution of liquid samples comprises a power-driven measuring valve having a rotatably mounted valve body provided with a single calibrated measuring passageway. During a dilution cycle the measuring passageway in different rotational positions of the valve body successively isolates a measured volume of a sample to be diluted and an equal volume of a first diluted solution of the sample which has been prepared by mixing the isolated undiluted volume of the sample with a measured volume of diluent. In a valve body position between said different rotational positions the measuring passageway is connected to form part of a rinsing flow system.
Claims4
A valve device for use in apparatus for serial dilution of liquid samples, comprising:
- (a) a valve housing having a sample inlet connectable to a source of liquid sample, a diluent inlet connectable to a source of liquid diluent, a third inlet and a first outlet, both being connectable to a first sample recipient, a second outlet connectable to a second sample recipient, pairs of first and second pump connection ports connectable to pump means for conveying liquid sample and diluent within said valve device, said pair of second pump connection ports forming said diluent inlet;
- (b) a valve body mounted in said housing for movement therein and having a passageway of predetermined volume opening into opposite surfaces of said valve body, said passageway in a first valve body position connecting said sample inlet with one of said pair of first pump connection ports, in a second valve body position connecting one of said pair of second pump connection ports with said first outlet, in a third valve body position connecting said third inlet with the other of said pair of first pump connection ports, and in a fourth valve body position connecting the other of said pair of second pump connection ports with the second outlet;
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- (c) a valve body actuator for selectively moving said valve body relative to said housing into one of said aforementioned valve body positions;
- (d) said housing having recesses which are open towards said opposite valve body surfaces and in register with the path along which the ends of said passageway move during movement of said valve body between said second and third valve body positions, said recesses being connectable with a wash liquid conveying system and in at least one valve body position between said second and third valve body positions communicating simeultaneously with said passageway.
Dependencies are inferred from the claim text.