Biodegradable amphipathic copolymers
AssigneeImperial Chemical Industries PLC
InventorsJeffrey R. Churchill, Francis G. Hutchinson
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Abstract
A pharmaceutically or veterinarily acceptable amphipathic, non-cross linked linear, branched or graft block copolymer, which has a minimum weight average molecular-weight of 1000, in which the hydrophobic component is biodegradable or hydrolytically unstable under normal physiological conditions, and the hydrophilic component may or may not be biodegradable or hydrolytically unstable under such conditions, and which copolymer is self-dispersible in water; together with mixtures of such a copolymer and a drug, which may be water-soluble of water-insoluble, which mixtures are self-dispersible in water; and processes for the manufacture of such copolymers and such mixtures.
Claims5
A pharmaceutically or veterinarily acceptable amphipathic block copolymer, which is self-dispersable in water to form a stable dispersion in water without the addition of any surfactant or other additive and has a minimum weight average molecular weight of 1000, selected from the group consisting of
- (a) non-cross-linked linear copolymers of the formula A.sub.m (BA).sub.n or B.sub.m (AB).sub.n ;
- and
- (b) non-cross-linked branched or graft block copolymers of the formula AB.sub.n or BA.sub.n wherein respectively A or B is a backbone polymer with n units of a monomer or polymer B or A
- respectively grafted onto it;
- wherein m is 0 or 1;
- n is an integer;
- wherein A is a pharmaceutically or veterinarily acceptable hydrophobic polymer which is biodegradable or hydrolytically unstable under normal physiological conditions and is selected from the group consisting of poly(D-, L- and DL-lactic acids);
- poly(D-, L-, and DL-lactides);
- polyglycolic acid;
- polyglycolide;
- poly-caprolactone;
- poly(3-hydroxybutyric acid);
- non-therapeutic hydrophobic polypeptides;
- polyacetals of the formula:
- ##STR5## wherein R is a hydrocarbon radical, and n is as previously defined;
- polycarbonates and polyorthoesters of the formula:
- ##STR6## wherein R and n are as previously defined;
- copolymers of the formula:
- ##STR7## wherein R and n are as previously defined;
- and copolymers derived from at least two monomers from which the above polymers are derived;
- and
- wherein B is a pharmaceutically or veterinarily acceptable hydrophilic polymer selected from the group consisting of polyvinylalcohol, polyvinylpyrrolidone, polyethylene glycol, polyacrylamide, polymethacrylamide, dextran, alginic acid, sodium alginate, gelatine, copolymers thereof, and polyoxyethylene/polyoxypropylene block copolymers.
Dependencies are inferred from the claim text.