Coprocessed microcrystalline cellulose and calcium carbonate composition and its preparation
AssigneeFMC Corporation
InventorsDev K. Mehra, Kenneth P. West, J. Donald Wiggins
Life of this patent
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Abstract
A particulate coprocessed microcrystalline cellulose and calcium carbonate composition having the respective components present in a weight ratio of from about 75:25 to 35:65. The composition is useful as a pharmaceutical excipient. The coprocessed composition is prepared by forming a well-dispersed aqueous slurry of microcrystalline cellulose and calcium carbonate and then drying the slurry, preferably by spray drying, to yield a particulate product.
Claims24
A composition of matter useful as a pharmaceutical excipient comprising dried particulate agglomerates of coprocessed microcrystalline cellulose and calcium carbonate, the two components being present in a weight ratio of from about 75:25 to 35:65 microcrystalline cellulose:calcium carbonate and intimately associated with each other.
A process for preparing a particulate material useful as a pharmaceutical excipient, which comprises
- forming a well-dispersed aqueous slurry of microcrystalline cellulose and calcium carbonate, both being present in particulate form and in amounts which produce a component ratio within the range specified below for the particulate coprocessed product, and
- drying the aqueous slurry by removing water therefrom to yield a particulate coprocessed product, in which the weight ratio of microcrystalline cellulose to calcium carbonate is in the range of from about 75:25 to 35:65.
A process for preparing a particulate material useful as a pharmaceutical excipient, which comprises
- dispersing microcrystalline cellulose and calcium carbonate, both in particulate form, into an aqueous medium to form a well-dispersed aqueous slurry containing relative amounts of microcrystalline cellulose and calcium carbonate that provide a component ratio within the range specified below for the particulate coprocessed product, and
- drying the aqueous slurry by removing water therefrom to yield a particulate coprocessed product, in which the weight ratio of microcrystalline cellulose to calcium carbonate is in the range of from about 75:25 to 35:65.
A process for preparing a particulate material useful as a pharmaceutical excipient, which comprises the steps of
- dispersing particulate microcrystalline cellulose into an aqueous medium in an amount of from about 5 to 25 wt % based on the slurry weight;
- introducing particulate calcium carbonate into the aqueous microcrystalline cellulose slurry in an amount which provides a component ratio within the range specified below for the particulate coprocessed product;
- dispersing the slurry solid components uniformly throughout the aqueous slurry, the amounts of solids previously introduced into the slurry being sufficient to provide a total solids content of at least 10 wt % based on total slurry weight;
- and
- spray drying the well-dispersed slurry to yield a particulate coprocessed product, in which the weight ratio of microcrystalline cellulose to calcium carbonate is in the range of from about 75:25 to 35:65.
Dependencies are inferred from the claim text.