Erodible matrix for sustained release bioactive composition
AssigneeZetachron, Inc.
InventorsWallace C. Snipes, Stephen J. Wagner
Life of this patent
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Abstract
A sustained release composition for releasing a biologically active compound into an aqueous liquid environment comprises the biologically active compound dispersed in a bioerodible matrix, the matrix comprising a mixture of (a.) 5% to 99.5% by weight of a solid water-dispersible polyether diol having a molecular weight from about 1000 to about 20,000, and (b.) 95 to 0.5% by weight of an erosion rate modifier component comprising a combination of stearyl alcohol and stearic acid. Dosage forms comprising the erodible matrix are prepared by molding, particularly by injection molding.
Claims85
A composition erodible by an aqueous liquid comprising
- 5 to 99.5% by weight of a polyethylene glycol having a molecular weight of from about 1000 to about 20,000, and
- 95 to 0.5% by weight of an erosion rate modifier component comprising a combination of stearyl alcohol and stearic acid.
A sustained release composition for releasing a biologically active compound into its surrounding environment comprising said biologically active compound dispersed in a matrix which, when contacted with an aqueous liquid, erodes progressively, said matrix comprising a mixture of
- 5 to 99.5% by weight of a polyethylene glycol having a molecular weight of from about 1000 to about 20,000, and
- 95to 0.5% by weight of an erosion rate modifier component comprising a combination of stearyl alcohol and stearic acid.
A sustained release composition for releasing a biologically active compound into its surrounding environment comprising a pharmaceutically active compound or non-toxic pharmaceutically acceptable salt of said pharmaceutically active compound dispersed in a matrix which, when contacted with an aqueous liquid, erodes progressively, said matrix comprising a mixture of
- 5 to 99.5% by weight of a polyethyene glycol having a molecular weight of from about 1000 to about 20,000, and
- 95to 0.5% by weight of an erosion rate modifier component comprising a combination of stearyl alcohol and stearic acid.
A sustained release composition for releasing an ecologically active compound into its surrounding environment comprising said ecologically active compound dispersed in a matrix which, when contacted with an aqueous liquid, erodes progressively, said matrix comprising a mixture of
- 5to 99.5% by weight of a polyethylene glycol having a molecular weight of from about 1000 to about 20,000, and
- 95 to 0.5% by weight of an erosion rate modifier component comprising a combination of stearyl alcohol and stearic acid.
A sustained release dosage form for releasing a biologically active compound into an aqueous liquid environment comprising a non-porous solid erodible matrix having dispersed therein a biologically active compound, said matrix comprising a mixture of
- 5to 99.5% by weight of a polyethylene glycol having a molecular weight of from about 1000 to about 20,000, and
- 95 to 0.5% by weight of an erosion rate modifier component comprising a combination of stearyl alcohol and stearic acid.
Dependencies are inferred from the claim text.