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OwnerJohn C. Boothroyd, George A. M. Cross +5inventors
InventorsJohn C. Boothroyd, George A. M. Cross, Michael D. Highfield, Michael D. Winther, David J. Rowlands, Fred Brown, Timothy J. R. Harris
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A DNA molecule comprising a nucleotide sequence substantially corresponding to all or a portion of foot and mouth disease virus RNA and in particular coding for at least one protein of foot and mouth disease virus. The DNA molecule can be inserted into a DNA cloning vehicle capable of expressing the DNA molecule, after a suitable host cell has been transformed by the cloning vehicle. The expression product can be incorporated into a vaccine for stimulating antibodies against FMDV. Methods for producing the DNA molecule, recombinant cloning vehicle and transformed host cell are described.
A recombinant DNA molecule comprising an expression vector DNA sequence and a nucleotide sequence coding for a polypeptide of foot and mouth disease virus (FMDV) serotype A functionally linked to a heterologus promoter, said polypeptide consisting essentially of (i) FMDV capsid protein VP.sub.1, being the capsid protein the gene for which is located closest to the 3'-end of the FMDV genome, alone or together with the whole or part of FMDV capsid protein VP.sub.3, the gene for which is adjacent to that of VP.sub.1, or (ii) an antigenic determinant of either of said proteins that is capable of eliciting an immune response to FMDV in a mammal.
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