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US 4,743,450 AGranted
Stabilized compositions
AssigneeWarner-Lambert Company
InventorsMichael Harris, Gerard Hokanson, Kuchi Murthy, Robert Reisch, Frank Waldman
Life of this patent
Estimating the term…
Abstract
The cyclization, hydrolysis, and coloration of certain ACE inhibitors is minimized when they are formulated with a metal-containing stabilizer and a saccharide.
Claims17
A pharmaceutical composition which contains:
- (a) a drug component which comprises a suitable amount of an ACE inhibitor which is susceptible to cyclization, hydrolysis, and discoloration,
- (b) a suitable amount of an alkali or alkaline earth metal carbonate to inhibit cyclization and discoloration, and
- (c) a suitable amount of a saccharide to inhibit hydrolysis.
A process for stabilizing an ACE inhibitor drug against cyclization which comprises the step of contacting the drug with:
- (a) a suitable amount of an alkali or alkaline earth-metal carbonate and,
- (b) one or more saccharides.
Dependencies are inferred from the claim text.