Antibiotic bonded prosthesis and process for producing same
AssigneeUniversity of Medicine and Dentistry of New Jersey
InventorsRalph S. Greco, Richard Harvey, Stanley Z. Trooskin
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Abstract
There is disclosed an improved prosthesis coated, respectively, with a cationic surfactant, an antibiotic compound and treated with an cationic exchange compound, to remove un-antibiotic bound cationic surfactant.
Claims27
A prosthesis for use in in vivo surgery having a coating, respectively, of a cationic surfactant and an antibiotic compound offering a charge opposite to that of said surfactant and bound to said surfactant, wherein said coating is discontinuous as to areas where said cationic surfactant lacks antibiotic bound thereto, said cationic surfactant having been removed in said areas the application thereto and removal of an immobilizing cationic exchange compound.
A method for preparing a prosthesis for use in in vivo surgery, which comprises:
- (a) contacting said prosthesis with a cationic surfactant to coat said prosthesis with said cationic surfactant;
- (b) contacting said prosthesis of step (a) with a solution of an antibiotic compound offering a charge opposite to that of said surfactant;
- and
- (c) contacting said prosthesis of step (b) with an cationic exchange compound to remove cationic surfactant not bound to said antibiotic compound.
Dependencies are inferred from the claim text.