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AssigneeAustralia Nuclear Science & Technology Organization
InventorsPhillip W. Moore, John M. Sodeau, Michael Shying, John V. Evans
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An initial aqueous pertechnetate solution which has a low electrolyte concentration compared with physiological saline is treated by passage through a bed of insoluble ion exchange material for adsorbing the pertechnetate. In a second step an ionic eluant having a smaller volume than the pertechnetate solution is passed through the bed to remove the pertechnetate to provide a relatively concentrated and pure eluate solution, the ion exchange material in the bed and the ionic eluant having respective properties for providing the eluate with a pH suitable for radiopharmaceutical purposes. The bed retains thereon radionuclidic impurities which may have been in the initial solution. The method can be valuable for treating the eluate from a portable technetium generator which is eluted with water and advantageously the insoluble material in the bed is zirconium oxide.
A method of treating an initial solution of pertechnetate in water comprising passing said initial pertechnetate solution through a bed of insoluble material having ion exchange properties for adsorbing the pertechnetate from said solution, and wherein the ion exchange material for said bed comprises a mixture of first and second hydrous metal oxide components, the first component being acid treated hydrous metal oxide and the second component being alkali treated hydrous metal oxide and in a second step passing an ionic eluant having smaller volume than said pertechnetate solution through the bed to remove the pertechnetate from the bed to provide a relatively concentrated and pure eluate solution, said ion exchange material in said bed and said ionic eluant having respective cooperating properties for providing said eluate with a pH in the range 4.0 to 8.0 and said bed retains thereon radionuclidic impurities in said initial solution.
A method of treating an aqueous initial pertechnetate solution which is a solution of pertechnetate in water comprising passing the initial pertechnetate solution though a bed of insoluble amphoteric ion exchange material comprising hydrous metal oxide for adsorbing pertechnetate from said solution, and passing through the bed isotonic saline solution having a smaller volume than said pertechnetate solution for removing pertechnetate from the bed whereby a relatively concentrated and pure eluate solution is provided for radiopharmaceutical purposes, the ion exchange material having the characteristic of providing the eluate with a pH in the range 4.0 to 8.0 and said bed retaining thereon radionuclidic impurities from said initial solution.
Dependencies are inferred from the claim text.