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US 4,737,323 AGranted
Liposome extrusion method
AssigneeLiposome Technology, Inc.
InventorsFrancis J. Martin, Jacqueline K. Morano
Life of this patent
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Abstract
A suspension of liposomes whose sizes are predominantly greater than about 1 micron is passed through an asymmetric ceramic filter whose inner-surface pore size is about 1 micron. The processed liposomes have a selected average size of about 0.4 microns or less, depending on the number of filter cycles, and a narrow distribution.
Claims7
A method of producing a suspension of liposomes which have uniform sizes and a selected average size of less than about 0.4 microns, said method comprising:
- providing a suspension of heterogeneous-size liposomes containing a substantial portion with sizes greater than 1.0 micron in size, and
- passing the suspension under pressure through an asymmetric ceramic filter whose inner-surface pore size is greater than the desired average liposome size and no greater than about 1 micron.
Dependencies are inferred from the claim text.