5,6-dihydroimidazo(2,1-b)thiazole-2-carboxamide derivatives or salts thereof
AssigneesKumiai Chemical Industry Co., Ltd., Toyo Jozo Kabushiki Kaisha
InventorsItaru Yamamoto, Kenji Matsunari, Koyata Nitta, Kensuke Shibata, Noriyasu Takayanagi
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Abstract
5,6-dihydroimidazo[2,1-b]thiazole-2-carboxamide derivatives represented by the following general formula [I] ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are either the same or different and mean individually a hydrogen atom or lower alkyl group, Y denotes a specific phenyl-containing substituted amino group, and their salts. These compounds have excellent immuno-modulating activities.
Claims12
A 5,6-dihydroimidazo[2,1-b]thiazole-2-carboxamide derivative represented by the following general formula [I] ##STR73## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are either the same or different and mean individually a hydrogen atom or lower alkyl group, Y denotes a group of the following formula:
- ##STR74## wherein A means a lower alkylene group which may be branched, R.sub.6 denotes a hydrogen atom or a lower alkyl or cycloalkyl group, X denotes a hydrogen or halogen atom or a trifluoromethyl, lower alkyl, lower alkoxy or nitro group, and n stands for an integer of 0-5, and when n is greater than 1, Xs are either the same or different;
- or a salt thereof.
N-(3,4-Dichloro benzyl)-N,3-dimethyl-5,6-dihydroimidazo[2,1-b]thiazole-2-carboxamide or a salt thereof.
N-(4-Triflu oromethylbenzyl)-N,3,6,6-tetramethyl-5,6-dihydroimidazo[2,1-b]thiazole-2-ca rboxamide or a salt thereof.
N-[2-(4-Chlorophenyl)ethy l]-N,3-dimethyl-5,6-dihydroimidazo[2,1-b]thiazole-2-carboxamide or a salt thereof.
N-(2-P henylethyl)-N,3,6,6-tetramethyl-5,6-dihydroimidazo[2,1-b]thiazole-2'-carbox amide or a salt thereof.
N-[2-(4-Chlorophenyl )ethyl]-N,3,6,6-tetramethyl-5,6-dihydroimidazo[2,1-b]thiazole-2-carboxamide or a salt thereof.
N-Benzyl-N,3,6, 6-tetramethyl-5,6-dihydroimidazo[2,1-b]-thiazole-2-carboxamide or a salt thereof.
N-(2- Phenylethyl)-3,6,6-trimethyl-5,6-dihydroimidazo[2,1-b]thiazole-2-carboxamid e or a salt thereof.
Dependencies are inferred from the claim text.