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US 4,736,025 AGranted
Process for the preparation of thienamycin and intermediates
AssigneeMerck & Co., Inc.
InventorsBurton G. Christensen, Ronald W. Ratcliffe, Thomas N. Salzmann
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Abstract
Disclosed is a process for the total synthesis of thienamycin from L-aspartic acid via intermediate III: ##STR1## R=H, blocking group or salt cation.
Claims1
The compound:
- ##STR31## wherein R.sup.1 is a synthesis protecting group and R.sup.2, R.sup.3, and R.sup.4 are independently selected from the group consisting of lower alkyl having 1-6 carbon atoms, aryl and aralkyl having 6 to 10 carbon atoms, wherein the aryl portion may also be substituted.
Dependencies are inferred from the claim text.