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US 4,736,018 AGranted
Blood coagulation inhibiting proteins, processes for preparing them and their uses
AssigneeBoehringer Ingelheim International GmbH
InventorChristian P. M. Reutelingsperger
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Abstract
This invention discloses proteins which inhibit the coagulation of the blood, processes for preparing these proteins, and the use thereof.
Claims4
A process for preparing an anti-coagulant protein from tissue which comprises:
- (a) homogenizing said tissue, differentially centrifuging said homogenized tissue, and subjecting the supernatant liquid to one or more of the following purification treatments in any desired sequence:
- (b) precipitation with salt,
- (c) affinity chromatography,
- (d) ion exchange chromatography,
- (e) chromatography using a molecular sieve;
- wherein said tissue is selected from the group consisting of blood vessel walls, highly vascularized tissue, or endothelial cell cultures.
3 more elements
Dependencies are inferred from the claim text.