Carboxylic acid amides and pharmaceutical compositions containing them

A compound of the formula ##STR29## wherein R.sub.1 and R.sub.2, together with the nitrogen atom to which they are attached, are di(alkyl of 1 to 3 carbon atoms)amino, N-(alkyl of 1 to 3 carbon atoms)-cyclohexylamino, (alkylene of 4 to 5 carbon atoms)-imino, (monomethyl-substituted alkylene of 4 to 5 carbon atoms)-imino, (dimethyl-substituted alkylene of 4 to 5 carbon atoms)-imino, 4-hydroxy-piperidino, piperid-4-on-1-yl, tetrahydropyridino, morpholino, thiomorpholino, N-methyl-piperazino, N-benzyl-piperazino, N-chlorophenyl-piperazino, hexamethyleneimino, heptamethyleneimino, octamethyleneimino, 3-aza-bicyclo[3,2,2]nonan-3-yl, 1,2,3,4-tetrahydro-isoquinolin-2-yl, 1,2,3,4,5,6,7,8-octahydro-isoquinolin-2-yl, decahydro-isoquinolin-2-yl, octahydroisoindol-2-yl or 8-aza-1,4-dioxa-spiro[4,5]decan-8-yl;

• R.sub.3 is hydrogen, fluorine, chlorine, bromine, iodine, methyl, hydroxyl, methoxy, benzyloxy, acetoxy, nitro, amino, acetylamino, methylsulfonylamino, benzoylamino, ethoxycarbonylamino, cyano, carboxyl, ethoxycarbonyl, aminocarbonyl or aminosulfonyl;
• R.sub.4 is hydrogen or methyl;
• R.sub.5 is hydrogen or, when W is carboxyl or (alkoxy of 1 to 4 carbon atoms) carbonyl, also chlorine;
• A is a single bond, dimethyl-methylene, ethylene, ##STR30## R.sub.6 and R.sub.7 are hydrogen or, together with the carbon atom to which they are attached, alkylidene of 2 to 5 carbon atoms, phenyl(alkylidene of 1 to 3 carbon atoms) or cyclohexylidene;
• R.sub.9 is hydrogen, alkyl of 1 to 5 carbon atoms, alkenyl of 3 to 5 carbon atoms, phenyl, halophenyl, methylphenyl, hydroxyphenyl, methoxyphenyl, benzyloxyphenyl, 4-methylmercaptophenyl, pyridyl, cyclohexyl, carboxyl, cyano, aminocarbonyl, methoxycarbonyl, ethoxycarbonyl, hydroxymethyl, methoxymethyl or phenyl(alkyl of 1 to 2 carbon atoms);
• B is methylene, ethylidene or ethylene;
• and
• W is methyl, hydroxymethyl, formyl, acetyl, carboxyl, cyano, 2-carboxy-ethenyl, 2-(alkoxy of 1 to 3 carbon atoms-carbonyl)-ethenyl, carboxy(alkyl of 1 to 2 carbon atoms), (alkoxy of 1 to 3 carbon atoms-carbonyl)-(alkyl of 1 to 2 carbon atoms), di(alkoxy of 1 to 3 carbon atoms-carbonyl)-(alkyl of 1 to 2 carbon atoms), (2,2-dimethyl-dioxolan-4-yl)methoxy-carbonyl, benzyloxy-carbonyl, aminocarbonyl, methylamino-carbonyl, dimethylaminocarbonyl, piperidino-carbonyl, morpholino-carbonyl, (alkoxy of 1 to 4 carbon atoms)-carbonyl;
• (mono- or dihydroxy-substituted alkoxy of 1 to 4 carbon atoms)-carbonyl, where individual methyl or methylene groups of the alkyl moiety are monohydroxy-substituted and the methylene group adjacent the oxygen atom is unsubstituted;
• or ##STR31## n is 2, 3 or 4;
• and R.sub.8 is methoxy, ethoxy, nicotinoyloxy, 1,3-dimethyl-xanthine-7-yl, dimethylamino or diethylamino;
• or a non-toxic, pharmacologically acceptable addition salt thereof.